Parker Scilog® NFF: Semi-automated Bioprocessing System

Parker’s SciLog® NFF automated single-use normal flow filtration (NFF) systems automatically monitor, adjust and document pressure and flow rate to optimise processing times, and maximise filter life and efficiency. By combining single-use sensing technology and automation, the need for constant monitoring during production runs is eliminated. The “open architecture” design enables any filter/membrane type to be used.

User-selectable end points and alarms automate the operation and ensure safe, consistent process performance. Patented, proprietary technology enables an automated feedback to protect the filter from over-pressurisation, controlling and maximising the throughput of the filter via SciPres® II pressure sensors incorporated within the fluid flowpath.

The system can communicate real-time process parameters via OPC to a plant historian and integrate with local Active Directory, or operate as a stand-alone unit. Up to two optional integrated scales can be used to deliver filtration precision by gravimetrically controlling operations.

Single Use Assembly Benefits

Safe, automated filtration improves filter throughput using the patented R/P Stat method
Flexible configuration for a wide range of applications
Optimised for Parker filters, but can accept other commercially available filters
Touch-screen interface for process monitoring and control
Integration with plant systems for data collection and process control
Small footprint
User configurable alarms and interlocks
An optional integrated scale for highly accurate filtration endpoints
Automated filter integrity testing
S88 Batch/Recipe configuration

Single Use Assembly Technical Data

Specifications Met: FDA 21 CFR Part 11, EudraLex Annex 11

Sensor Connection: 3x Pressure Sensor Connections (DIN)

Pump Type: Peristaltic or Diaphragm

Flow Rate: 0.2 to 83 L/min

MODES OF CONTROL

Constant Flow – Maintains pump rate and monitors pressure. The system will ensure that pressure does not exceed a high limit set point.
Constant Pressure – Maintains pressure, regulating flow rate. The system will ensure that pressure does not exceed a maximum set point.
R/P Stat Method – The system maintains a constant pump flow rate, monitoring pressure until a pressure limit is reached. The system immediately switches to constant pressure mode, monitoring flow rate until a minimum set point is reached.
Manual Operation – User-definable motor set point

MATERIALS OF CONSTRUCTION

304L stainless steel framework (316L on request)
Mobile platform with pharmaceutical-grade casters. IPx5

Single Use Assembly Application

Normal flow filtration

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